The rise of China and decline of the eurozone are two themes that continue to dominate the top end of the Top 1000. But some equally significant changes are taking place further down the rankings.
South Africa's lenders still dominate Africa's banking landscape, but their sluggish 2012 means that the rest are making up ground.
Slow but steady growth seems to be the order of the day for banks in the Middle East, with most countries in the region having something to cheer.
Although Brazil's largest four banks remain well clear of the pack in Latin America, there were promising developments in Colombia, Mexico and Venezuela in 2012.
There is a new largest bank in North America, with Bank of America losing ground to JPMorgan.
The Tier 1 capital of the 25 largest central and eastern European banks climbed by 30% in this year's ranking, led by Russia's largest bank Sberbank. Meanwhile, consumer banking operations across the region are prominent among the most profitable and the fastest growing banks in the region.